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Recombinant Human CXCL1 (Mammalian, C-6His)

Cat. No. M25411
Recombinant Human CXCL1 (Mammalian, C-6His) Structure
Synonym:

C-X-C Motif Chemokine 1

Size Price Availability Quantity
10ug USD 168  USD168 In stock
50ug USD 360  USD360 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.01 EU/μg
  • COA
  • MSDS
Biological Activity

Chemokine (C-X-C motif) Ligand 1 Protein (CXCL1) is a growth factor for melanoma cells and a chemotaxin for neutrophils and a member of the CXC chemokine family that is a potent neutrophil attractant and activator and is also active toward basophils. CXCL1 is expressed by macrophages, neutrophils and epithelial cells; it has neutrophil chemoattractant activity. Recombinant Human CXCL1 is produced by Mammalian expression system and the target gene encoding Ala35-Asn107 is expressed with a 6His tag at the C-terminus.


Accession: P09341

APMol Mass: 10-14 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, pH 7.4.

Chemical Information
Solubility (25°C) Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days, at ≤ -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gaia Bellomo, et al. Gut. Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis

[2] Huazhi Zhang, et al. Autophagy. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis

[3] Shanshan Cai, et al. Mucosal Immunol. NLRP6 modulates neutrophil homeostasis in bacterial pneumonia-derived sepsis

[4] Zhen-Yu Liu, et al. Theranostics. RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression

[5] Chongbiao Huang, et al. Gastroenterology. Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice

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Keywords: Recombinant Human CXCL1 (Mammalian, C-6His), C-X-C Motif Chemokine 1 supplier, Recombinant Proteins, inhibitors, activators


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