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Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily.
Recombinant Human Cytotoxic T-lymphocyte Protein 4 expressed the target gene encoding Lys36-Asp161 with a 6His tag at the C-terminus.
Accession: P16410
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 20-25 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
[1] Qingqing Xiao et al. Acta Pharm Sin B. Biological drug and drug delivery-mediated immunotherapy
[4] Drew M Pardoll. Nat Rev Cancer. The blockade of immune checkpoints in cancer immunotherapy
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Products are for research use only. Not for human use. We do not sell to patients.
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