Species: Homo sapiens (Human)
Predicted molecular weight: 33.46 kDa
Purity: sdS-PAGE determination was >90%
Stability and storage: use manual defrosting refrigerator to avoid repeated freeze-thaw cycles. Store at 2-8 °C for one week. Store at -20 to -80°C for 12 months from date of receipt.
Biological activity: Can activate a variety of chemokine receptors, including CCR1, CCR3, CCR4 and CCR5. A major HIV suppressor is produced by CD8+ T cells. Recombinant RANTES protein induces dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). As a natural chemotactic inhibitor, processed RANTES(3-68) is a more potent inhibitor of HIV-1 infection. The second treated RANTES(4-68), which is produced by an unknown enzyme associated with monocytes and neutrophils, showed lower chemotaxis and hiv-inhibiting activity compared to RANTES(1-68) and RANTES(3-68). It may also be an agonist of the G-protein-coupled receptor GPR75, through which activation stimulates inositol triphosphate production and calcium mobilization. Together with GPR75, it may play a role in neuronal survival by activating downstream signaling pathways involving PI3, Akt, and MAP kinases. Activation of GPR75 may also play a role in insulin secretion by islet cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Cytokines Products|
Recombinant Human Dickkopf-related protein 1 is produced by our Mammalian expression system and the target gene encoding Thr32-His266 is expressed with a 8His tag at the N-terminus.
|FGF-basic, Rat（E. coli）
FGF-basic, Rat（E. coli） Expressed with an n-terminal Gly. FGF-basic (Pro10-Ser154) Accession # P13109. Bioactivity: ED50 < 0.25 ng/ mL, measured by 3T3 cell proliferation method, corresponding to > 4.0 × 106 units /mg.
|TNF-α, Human (E. coli)
TNF-α, Human (E. coli) Protein structure: TNF-α (VAL77-LEU233) Accession # P01375. Bioactivity: ED50 < 30.0 pg/ mL, measured in cytotoxicity assay of L-929 mouse fibrosarcoma cells in the presence of metabolic inhibitor actinomycin D, corresponding specific activity > 3.3 × 107 units /mg.
|BMP-2, Human（E. coli）
BMP-2, Human（E. coli） Protein structure: BMP-2 (GLN283-ARG396) Accession # P12643. Biological activity: Experiment 1: To determine its ability to induce alkaline phosphatase production in ATDC-5 cells. The ED50 for this effect is generally 0.07-0.2µg/ mL. Experiment 2: The ability of inducing ALKALINE phosphatase production in C2C12 cells was determined. The ED50 for this effect is usually 0.2-1µg/ mL.
|SCF, Human (P. pastoris)
SCF, Human (P. pastoris) The protein was Expressed with an n-terminal Met. SCF (Glu26-Ala189) Accession # P21583-1. Biological activity: ED50 was < 2.0 ng/ mL by dose-dependent tF-1 cell stimulation, corresponding specific activity was 5 × 105IU /mg.
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