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Recombinant Human CCL5 protein(E.coli)

Cat. No. M11471
Recombinant Human CCL5 protein(E.coli) Structure
Size Price Availability Quantity
100ug USD 490  USD490 In stock
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Quality Control
  • Current batch:
  • Purity >90%
  • COA
  • MSDS
Biological Activity

Species: Homo sapiens (Human)
Predicted molecular weight: 33.46 kDa
Purity: sdS-PAGE determination was >90%
Stability and storage: use manual defrosting refrigerator to avoid repeated freeze-thaw cycles. Store at 2-8 °C for one week. Store at -20 to -80°C for 12 months from date of receipt.


Biological activity: Can activate a variety of chemokine receptors, including CCR1, CCR3, CCR4 and CCR5. A major HIV suppressor is produced by CD8+ T cells. Recombinant RANTES protein induces dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). As a natural chemotactic inhibitor, processed RANTES(3-68) is a more potent inhibitor of HIV-1 infection. The second treated RANTES(4-68), which is produced by an unknown enzyme associated with monocytes and neutrophils, showed lower chemotaxis and hiv-inhibiting activity compared to RANTES(1-68) and RANTES(3-68). It may also be an agonist of the G-protein-coupled receptor GPR75, through which activation stimulates inositol triphosphate production and calcium mobilization. Together with GPR75, it may play a role in neuronal survival by activating downstream signaling pathways involving PI3, Akt, and MAP kinases. Activation of GPR75 may also play a role in insulin secretion by islet cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >90%
Solubility N/A
Storage at -20°C
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