Catalase (CAT) is a member of the catalase family. Catalase promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells, and normal and transformed fibroblast cells. It exists as a homotetramer that occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Recombinant Human Catalase expressed the target gene encoding Ala2-Leu527.
Accession: P04040
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 60 KDa, reducing conditions
Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
The product is shipped on dry ice. Upon receipt, store it immediately at the temperature listed below.
| Form | Solution |
| Storage |
Store at ≤ -70°C, stable for one year after receipt. Stored at ≤ -20°C, stable for 3 months after receipt. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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