Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/ug (1 EU/ug) as tested by LAL
Storage and stability: storage temperature ≤-70℃, after receiving the goods can be stably stored for 6 months. After opening, store in aseptic condition for 3 months, storage temperature ≤-70℃. Please minimize freeze-thaw cycles.
Bioactivity: CPE is active in the form of cleaving c-terminal amino acid residues of peptides, and therefore participates in biosynthesis of peptide hormones and neurotransmitters such as insulin and enkephalin. Membrane-associated CPE acts as a sorting receptor, targeting the regulation of secretory proteins, mainly the pituitary gland across the Golgi network and secretory granules in the prehormonal and neuropeptides into secretory pathways. Defects in the protein are associated with type 2 diabetes and can lead to impaired glucose clearance and insulin resistance.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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