Recombinant Human BMP-5 Protein is a biologically active C-terminal mature protein cleaved from a 454 amino acid precursor protein. Recombinant Human BMP-5 is expressed in the nervous system, lung and liver. It is a regulator of the growth of sympathetic neuron dendritic cells. BMP-5 initiates, promotes and regulates the development, growth and remodeling of bone and cartilage. BMP family factors are also involved in prenatal and postnatal growth, remodeling and maintaining various other tissues and organs.
The recombinant human BMP-5 protein contains 376 amino acids and the predicted molecular weight is 42.6kd.
Depends on its ability to induce ATDC-5 cells to produce alkaline phosphatase, the expected effectiveness of ED50 is 1.0-2.0 μg/ml.
Expression host is Human HEK293 cells
| Solubility (25°C) | Water Saline PBS |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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