All AbMole products are for research use only, cannot be used for human consumption.
Recombinant Human BMP-2 Protein (HEK293) is a powerful osteoinductive cytokine that can be combined with collagen and synthetic hydroxyapatite and other osteoconductive carriers to induce the formation of bone and cartilage. BMP-2 also plays an important role in cardiac morphogenesis, and is expressed in lung, liver, spleen, prostate, ovary and small intestine and other tissues. The functional form of BMP-2 is a 26 kDa protein, which is composed of two identical 114 amino acid polypeptide chains (monomers) connected by a single disulfide bond. Each bmp-2 monomer is expressed as the C-terminal part of the precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion and a 259 amino acid precursor. After the precursor is dimerized, the covalent bond between the propeptide (which is also a homodimer of disulfide bonds) and the mature BMP-2 ligand is cleaved by the furan-type protease.
The recombinant human BMP-2 protein contains 352 amino acids and the predicted molecular weight is 39.8kd.
Measured by its ability to induce ATDC-5 cells to produce alkaline phosphatase, the ED50 is ≤1μg/mL.
Endotoxin <0.1EU/μg
Expression host is Human HEK293 cells
J Gastroenterol Hepatol. 2025 Mar 26.
The Role of BMP2/4 in Intestinal Ischemia‐Reperfusion Injury: Bridging Smad1/5 and Notch Pathways via Smad6
Recombinant Human BMP-2 Protein (HEK293, C-Fc) purchased from AbMole
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml. |
| Storage | Stored at ≤-20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Related Cytokines and Growth Factors Products |
|---|
| Recombinant Human GDF-15 Protein (HEK293 N-hFc)
Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily. GDF-15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
| Recombinant Human FGFR1 Protein (HEK293, C-His)
FGFR1, also known as CD331, is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. |
| Recombinant Human FGFR2 Protein (HEK293, C-His)
FGFR2, also known as CD332, acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. |
| Recombinant Mouse BMP-4 Protein (E. coli, C-His)
Bone Morphogenetic Protein-4 (BMP-4) is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP-4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog to establish a dorsal-ventral axis for the differentiation of later structures. |
| Recombinant Human Coagulation Factor X (HEK293, C-Fc)
Coagulation factor X, belongs to the peptidase S1 family. Coagulation factor X is initially synthesized in the liver. Coagulation factor X is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
