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Recombinant Human BMP-2 Protein

Cat. No. M9990
Recombinant Human BMP-2 Protein Structure
Size Price Availability Quantity
10ug USD 178.2  USD198 In stock
50ug USD 412.2  USD458 In stock
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Quality Control
  • Current batch:
  • Purity ≥95%, Endotoxin ≤0.01EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human BMP-2 Protein is a powerful osteoinductive cytokine that can be combined with collagen and synthetic hydroxyapatite and other osteoconductive carriers to induce the formation of bone and cartilage. BMP-2 also plays an important role in cardiac morphogenesis, and is expressed in lung, liver, spleen, prostate, ovary and small intestine and other tissues. The functional form of BMP-2 is a 26 kDa protein, which is composed of two identical 114 amino acid polypeptide chains (monomers) connected by a single disulfide bond. Each bmp-2 monomer is expressed as the C-terminal part of the precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion and a 259 amino acid precursor. After the precursor is dimerized, the covalent bond between the propeptide (which is also a homodimer of disulfide bonds) and the mature BMP-2 ligand is cleaved by the furan-type protease.

The recombinant human BMP-2 protein contains 352 amino acids and the predicted molecular weight is 39.8kd.

Depends on its ability to induce ATDC-5 cells to produce alkaline phosphatase, the expected ED50 effectiveness is 40-100 ng/ml.

Expression host is Human HEK293 cells

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity ≥95%, Endotoxin ≤0.01EU/ug
Solubility Water
Saline
PBS
Storage 2-8°C, dry, sealed
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