Recombinant Human BAFF Protein is a member of the tumor necrosis factor (TNF) family and is expressed in T cells, macrophages, monocytes and dendritic cells, stimulating the functions of B cells and T cells, and is an important factor for the survival and maturation of peripheral B cells. BAFF signals through three different TNF receptors TACI, BCMA and BAFF-R.
Determined by dose-dependent mitogenic activity on human RPMI 8226 cells, the ED50 is < 20.0 ng/ml, corresponding to a specific activity of > 5.0 x 104 units/mg.
Accession: Q9Y275
Endotoxin < 0.2 EU/μg
Apparent Molecular Weight: ~17 kDa
Lyophilized after extensive dialysis against PBS.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml. |
| Storage | Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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