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Recombinant Human B4GALT1 (Mammalian, C-6His)

Cat. No. M19993
Recombinant Human B4GALT1 (Mammalian, C-6His) Structure
Synonym:

1,4- galactosyltransferase, polypeptide 1; B4GalT1

Size Price Availability
10ug USD 208  USD260 1-2 Weeks
50ug USD 576  USD720 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: Mammalian
Apparent molecular weight: 50-60 kDa, reduction conditions
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Purity: > 95% as determined by reduced SDS-PAGE
Storage and stability: Storage temperature ≤-70℃, stable storage for 6 months after receiving goods. After opening, store in aseptic condition for 3 months, storage temperature ≤-70℃. Please minimize freeze-thaw cycles.


Bioactivity: Beta1,4-Galactosyltransferase-I (B4GALT1), one of seven beta1,4-galactosyltransferases, is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides. By sequence similarity, the beta 4GalTs form four groups: beta 4GalT1 and beta 4GalT2, beta 4GalT3 and beta 4GalT4, beta 4GalT5 and beta 4GalT6, and beta 4GalT7. beta 4GalT1 is unique among the seven enzymes because it can be expressed either as membrane associated form or secreted form. The secreted form is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha -lactalbumin to catalyze the synthesis of lactose. The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix. Defects in beta 4GalT1 are the cause of congenital disorder of glycosylation type 2D (CDG2D) .

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 1 EU/µg
Solubility
Storage at -20°C
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Keywords: Recombinant Human B4GALT1 (Mammalian, C-6His), 1,4- galactosyltransferase, polypeptide 1; B4GalT1 supplier, Cytokines, inhibitors

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