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Recombinant Human Asprosin (HEK293, N-8His)

Cat. No. M21700

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human Asprosin (HEK293, N-8His) Structure
Synonym:

Fibrillin-1; FBN1

Size Price Availability Quantity
10ug USD 220  USD220 In stock
50ug USD 620  USD620 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Recombinant Human Asprosin is produced by Mammalian expression system and the target gene encoding Ser2732-His2871 is expressed with a 8His tag at the N-terminus. Asprosin is a fasting-induced glucogenic protein hormone. In the liver asprosin activates rapid glucose release by a cAMP-dependent pathway. The glucose release by the liver into the blood stream is vital for brain function and survival during fasting. People with neonatal progeroid syndrome lack asprosin, while people with insulin resistance have it in abundance. In animal tests asprosin showed potential for treating type 2 diabetes.


Accession: P35555

Endotoxin: < 1 EU/µg

APMol Mass: 25-35 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Kiran Shabir, et al. Int J Mol Sci. Asprosin Exerts Pro-Inflammatory Effects in THP-1 Macrophages Mediated via the Toll-like Receptor 4 (TLR4) Pathway

[2] Ila Mishra, et al. STAR Protoc. Overexpression and ELISA-based detection of asprosin in cultured cells and mice

[3] Xuejing Wei, et al. Nan Fang Yi Ke Da Xue Xue Bao. [Expression, purification and functional assessment of asprosin inclusion body]

[4] Taeseung Lee, et al. Mol Cell Endocrinol. Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation

[5] Chase Romere, et al. Cell. Asprosin, a Fasting-Induced Glucogenic Protein Hormone

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Keywords: Recombinant Human Asprosin (HEK293, N-8His), Fibrillin-1; FBN1 supplier, Cytokines and Growth Factors, inhibitors, activators

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