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Recombinant Human Arylsulfatase A/ARSA (Mammalian, C-6His)

Cat. No. M21212
Recombinant Human Arylsulfatase A/ARSA (Mammalian, C-6His) Structure
Synonym:

Arylsulfatase A; ASA; Cerebroside-Sulfatase; ARSA

Size Price Availability Quantity
10ug USD 156  USD195 In stock
50ug USD 404  USD505 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: Mammalian
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Molecular weight: 52.9 KDa
Storage and Stability: Stored at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months after opening under sterile conditions. Please minimize freeze-thaw cycles.


Bioactivity: Arylsulfatase A (ARSA) is a lysosomal enzyme that breaks down cerebroside 3-sulfate, a major component of myelin sheets, into cerebroside and sulfate.ARSA deficiency causes metachromatic leukodystrophy (MLD), a lysosomal storage disease of the central and peripheral nervous system with severe and progressive neurological symptoms. Recombinant human ARSA corresponds to the ARSA maturation peptide and has sulfatase activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 1 EU/µg
Solubility
Storage at -20°C
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Keywords: Recombinant Human Arylsulfatase A/ARSA (Mammalian, C-6His), Arylsulfatase A; ASA; Cerebroside-Sulfatase; ARSA supplier, Cytokines, inhibitors

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