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Species: Human
Expression system: Mammalian
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Molecular weight: 52.9 KDa
Storage and Stability: Stored at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months after opening under sterile conditions. Please minimize freeze-thaw cycles.
Bioactivity: Arylsulfatase A (ARSA) is a lysosomal enzyme that breaks down cerebroside 3-sulfate, a major component of myelin sheets, into cerebroside and sulfate.ARSA deficiency causes metachromatic leukodystrophy (MLD), a lysosomal storage disease of the central and peripheral nervous system with severe and progressive neurological symptoms. Recombinant human ARSA corresponds to the ARSA maturation peptide and has sulfatase activity.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | |
| Formula | |
| CAS Number | |
| Purity | >95% , Endotoxin < 1 EU/µg |
| Solubility | |
| Storage | at -20°C |
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