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Recombinant Human Arylsulfatase A/ARSA (HEK293, C-6His)

Cat. No. M21212

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human Arylsulfatase A/ARSA (HEK293, C-6His) Structure
Synonym:

Arylsulfatase A; ASA; Cerebroside-Sulfatase; ARSA

Size Price Availability Quantity
10ug USD 195  USD195 In stock
50ug USD 505  USD505 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Arylsulfatase A (ARSA) is a lysosomal enzyme that breaks down cerebroside 3-sulfate, a major component of myelin sheets, into cerebroside and sulfate. ARSA deficiency causes metachromatic leukodystrophy (MLD), a lysosomal storage disease of the central and peripheral nervous system with severe and progressive neurological symptoms. Recombinant human ARSA corresponds to the ARSA maturation peptide and has sulfatase activity.


Accession: AAH14210.2

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 50-65 KDa, reducing conditions

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, pH 8.0.

The product is shipped on dry ice. Upon receipt, store it immediately at the temperature listed below.

Chemical Information
Form Solution
Storage Store at ≤ -70°C, stable for 6 months after receipt.
References

[1] Jun Sung Lee, et al. Brain. Arylsulfatase A, a genetic modifier of Parkinson's disease, is an α-synuclein chaperone

[2] Sandra Pajarola, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Measurement of recombinant human arylsulfatase A and leukocyte sulfatase activities by analytical isotachophoresis

[3] Jonas Doerr, et al. Mol Ther. Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy

[4] Alessandra Biffi, et al. Science. Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

[5] Kazumasa Fujita, et al. Connect Tissue Res. Mammalian arylsulfatase A functions as a novel component of the extracellular matrix

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Keywords: Recombinant Human Arylsulfatase A/ARSA (HEK293, C-6His), Arylsulfatase A; ASA; Cerebroside-Sulfatase; ARSA supplier, Cytokines and Growth Factors, inhibitors, activators

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