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Recombinant Human ANXA2 Protein (E. coli)

Cat. No. M45127
Recombinant Human ANXA2 Protein (E. coli) Structure
Synonym:

Annexin A2; Annexin II

Size Price Availability Quantity
10ug USD 205  USD205 In stock
50ug USD 540  USD540 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. ANXA2 functions as an autocrine factor, it can increases osteoclast formation and bone resorption. ANXA2 protein is associated with sickle cell osteonecrosis and the expression reduce of ANXA2 is associated with osteosarcoma metastases. ANXA2 is involved in muscular dystrophies.

Recombinant Human Annexin A2 expressed the target gene encoding Ser2-Asp339.


Accession: P07355

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 35 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM Histidine-HCl, 6% Sucrose, 4% Mannitol, 0.05%Tween 80, pH 5.5.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Human ANXA2 Protein (E. coli), Annexin A2; Annexin II supplier, Recombinant Proteins, inhibitors, activators


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