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Recombinant Human ANGPTL4 (Mammalian, N-6His)

Cat. No. M22506
Recombinant Human ANGPTL4 (Mammalian, N-6His) Structure
Synonym:

Angiopoietin Like Protein 4; Angiopoietin-related protein 4

Size Price Availability Quantity
10ug USD 125  USD125 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Recombinant Human Angiopoietin Like Protein 4 is produced by Mammalian expression system and the target gene encoding Pro166-Ser406 is expressed with a 6His tag at the N-terminus. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). Angiopoietin-related protein 4(ANGPTL4)is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.


Accession: Q9BY76

APMol Mass: 32-38 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 100mM NaCl, pH7.4.

Chemical Information
Solubility (25°C) Dissolve the lyophilized protein in distilled water.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuyue Zuo, et al. Front Pharmacol. ANGPTL4 Regulates Psoriasis via Modulating Hyperproliferation and Inflammation of Keratinocytes

[2] Lei Dai, et al. Front Endocrinol (Lausanne). Weighted Gene Co-Expression Network Analysis Identifies ANGPTL4 as a Key Regulator in Diabetic Cardiomyopathy via FAK/SIRT3/ROS Pathway in Cardiomyocyte

[3] Wen-Hsuan Yang, et al. Mol Cancer Res. A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer

[4] Antwi-Boasiako Oteng, et al. J Lipid Res. Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice

[5] Ke-qiang Li, et al. Chin Med J (Engl). Anti-tumor effect of recombinant retroviral vector-mediated human ANGPTL4 gene transfection

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Keywords: Recombinant Human ANGPTL4 (Mammalian, N-6His), Angiopoietin Like Protein 4; Angiopoietin-related protein 4 supplier, Recombinant Proteins, inhibitors, activators


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