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Recombinant Human AMH Protein (HEK293, His Tag)

Cat. No. M22450
Recombinant Human AMH Protein (HEK293, His Tag) Structure
Synonym:

Anti-Mullerian; Mullerian Inhibitory

Size Price Availability Quantity
50ug USD 900  USD900 In stock
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Quality Control & Documentation
  • Purity: >90%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Anti-Mullerian hormone (AMH/MIS), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles. AMH is widely used for assessing ovarian reserve, and it is particularly convenient, because it is thought to have minimal variability throughout the menstrual cycle. AMH can also be used as a surrogate diagnostic marker of polycystic ovary syndrome (PCOS).

AMH is responsible for normal male sexual differentiation, and circulating AMH is used as a marker of testicular tissue in newborns with disorders of sex development. Anti-Mullerian hormone (AMH) produced in the developing testis induces the regression of the Mullerian duct, which develops into the oviducts, uterus and upper vagina. As well as other hormone receptors, and a decreased ovarian cortex cell proliferation.


The recombinant human AMH consists of 555 amino acids and predicts a molecular mass of 59.1 kDa.

A DNA sequence encoding the human AMH (NP_000470.2) (Leu25-Arg560) was expressed with a polyhistidine tag at the N-terminus.

Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 8.0.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 250 μg/ml.
Storage Stable for up to twelve months from date of receipt at -20℃ to -80℃
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Craig A Witz, et al. Fertil Steril. Randomized, assessor-blinded trial comparing highly purified human menotropin and recombinant follicle-stimulating hormone in high responders undergoing intracytoplasmic sperm injection

[2] Vitaly A Kushnir, et al. J Assist Reprod Genet. Potential therapeutic applications of human anti-Müllerian hormone (AMH) analogues in reproductive medicine

[3] P Humaidan, et al. Hum Reprod. Efficacy and safety of follitropin alfa/lutropin alfa in ART: a randomized controlled trial in poor ovarian responders

[4] Anders Nyboe Andersen, et al. Fertil Steril. Individualized versus conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial

[5] Rong Hu, et al. Cell Biochem Biophys. Effects of recombinant human AMH on SCF expression in human granulosa cells

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Keywords: Recombinant Human AMH Protein (HEK293, His Tag), Anti-Mullerian; Mullerian Inhibitory supplier, Recombinant Proteins, inhibitors, activators


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