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Ractopamine hydrochloride

Cat. No. M2973
Ractopamine hydrochloride Structure
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1g USD 380  USD380 Custom Synthesis
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Quality Control & Documentation
Biological Activity

Ractopamine hydrochloride (RAC), a beta-agonist with established nutrient partitioning capabilities, promotes skeletal muscle accretion at the expense of fat deposition.

Chemical Information
Molecular Weight 337.84
Formula C18H23NO3.HCl
CAS Number 90274-24-1
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bailey N Harsh, et al. Effects of ractopamine hydrochloride on nutrient digestibility and nitrogen excretion of finishing beef cattle

[2] Phillip J Rincker, et al. Effects of voluntary removal of ractopamine hydrochloride (Optaflexx) on live performance and carcass characteristics of beef steers

[3] Elizabeth G Ross, et al. Effect of ractopamine hydrochloride on environmental gas emissions, growth performance, and carcass characteristics in feedlot steers

[4] Cristiane Garbinato, et al. Exposure to ractopamine hydrochloride induces changes in heart rate and behavior in zebrafish embryos and larvae

[5] Adrieli Sachett, et al. Ractopamine hydrochloride induces behavioral alterations and oxidative status imbalance in zebrafish

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