(Rac)-CPI-098 shows antibacterial activity. (Rac)-CPI-098 exhibits superior anti-fungal activity against Monascus ruber, better activity against Aspergillus fumigates, good activity against Aspergillus niger and Aspergillus parasites and moderate activity against Candida albicans.
| Molecular Weight | 176.22 |
| Formula | C10H12N2O |
| CAS Number | 3967-01-9 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Kei-Ichi Katayama, et al. Exp Neurol. Rac is required for the survival of cortical neurons
[3] Ian Aj Lorimer. Small GTPases. Aberrant Rac pathway signalling in glioblastoma
[4] María Del Mar Maldonado, et al. Cancer Res. Targeting Rac and Cdc42 GTPases in Cancer
[5] Carlo C Campa, et al. Small GTPases. Crossroads of PI3K and Rac pathways
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