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(Rac)-Brassinazole

Cat. No. M9684
(Rac)-Brassinazole Structure
Size Price Availability Quantity
5mg USD 550  USD550 In stock
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

(Rac)-Brassinazole is a brassinosteroid (BR) biosynthesis inhibitor. (Rac)-Brassinazole increases inhibition of CYP90B in BR biosynthesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 327.81
Formula C18H18ClN3O
CAS Number 224047-41-0
Purity >95%
Solubility DMSO
Storage 2-8°C, dry, protect from light, sealed
References

[1] Y K Min, et al. Bioorg Med Chem Lett. New lead compounds for brassinosteroid biosynthesis inhibitors

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Keywords: (Rac)-Brassinazole supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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