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(R)-(-)-α-Methylhistamine dihydrobromide

Cat. No. M30758

All AbMole products are for research use only, cannot be used for human consumption.

(R)-(-)-α-Methylhistamine dihydrobromide Structure

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Quality Control & Documentation
Biological Activity

(R)-(-)-α-Methylhistamine dihydrobromide is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM. (R)-(-)-α-Methylhistamine dihydrobromide can enhance memory retention, attenuates memory impairment in rats.

Chemical Information
Molecular Weight 287
Formula C6H13Br2N3
CAS Number 868698-49-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Jian Xu, et al. J Biol Chem. The histamine H3 receptor modulates dopamine D2 receptor-dependent signaling pathways and mouse behaviors

[2] Jia-Ji Lin, et al. Oncotarget. Inhibition of histamine receptor 3 suppresses glioblastoma tumor growth, invasion, and epithelial-to-mesenchymal transition

[3] Heather Francis, et al. Mol Cancer Res. H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo

[4] Heather Francis, et al. Lab Invest. H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway

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Keywords: (R)-(-)-α-Methylhistamine dihydrobromide supplier, Histamine Receptor, inhibitors, activators

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