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-CR8 trihydrochloride.gif)
(R)-CR8 trihydrochloride, one of the isomers of CR8, is a potent CDK1/2/5/7/9 inhibitor with anti-proliferative and pro-apoptotic effects on CML cell lines. (R)-CR8 trihydrochloride inhibited CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM ), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM).
| Molecular Weight | 468 |
| Formula | C24H30ClN7O |
| CAS Number | 1786438-30-9 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | 2-8°C, dry, sealed |
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| CDK9-IN-1
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| XO44
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| ML 315
ML 315 is a selective dual inhibitor of CDK and DYRK with IC50s of 68 nM and 282 nM, respectively. |
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