Product Name:	(R)-CR8 trihydrochloride
Catalog Number:	M21148
CAS Number:	1786438-30-9

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Physical and Chemical Properties

Formula:	C24H30ClN7O
Molecular Weight:	468
Solubility:	DMSO ≥ 60 mg/mL
Storage:	2-8°C, dry, sealed
Chemical Structure:

Analytical Data

QC Standard:	>98.0%
H-NMR:	Consistent with structure

Product Information

Description:	(R)-CR8 trihydrochloride, one of the isomers of CR8, is a potent CDK1/2/5/7/9 inhibitor with anti-proliferative and pro-apoptotic effects on CML cell lines. (R)-CR8 trihydrochloride inhibited CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM ), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM).
Stability and Solubility Advice:	Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.

AbMole BioScience

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