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Quininib is a cell penetrant, potent and selective cysteinyl leukotriene receptor 1 and 2 (CysLT1-2) antagonist that potently inhibits angiogenesis in a range of cell and tissue systems. Quininib inhibits retinal revascularisation in OIR mice. Quininib is effective at inhibiting angiogenesis in the mouse oxygen-induced retinopathy model. Additionally quininib inhibits endothelin-converting enzyme-2 (ECE-2).
| Molecular Weight | 247.29 |
| Formula | C17H13NO |
| CAS Number | 143816-42-6 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Niamh Mahon, et al. Discovery and Development of the Quininib Series of Ocular Drugs
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