Free shipping on all orders over $ 500

Quinacrine dihydrochloride

Cat. No. M3183
Quinacrine dihydrochloride Structure

Mepacrine dihydrochloride; SN-390

Size Price Availability Quantity
100mg USD 60  USD60 In stock
200mg USD 80  USD80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Quinacrine dihydrochloride is an inhibitor of cPLA2, MAO-A and MAO-B. Quinacrine dihydrochloride is a non-specific PLA2 (phospholipase A2) inhibitor. Quinacrine dihydrochloride acts as an AChR (acetylcholine receptor) antagonist. Quinacrine dihydrochloride suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 μM).

Chemical Information
Molecular Weight 472.88
Formula C23H30ClN3O.2HCl
CAS Number 69-05-6
Solubility (25°C) DMSO 30 mg/mL
Water 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Clemence Delaye, et al. Access and use of quinacrine (mepacrine) in the treatment of resistant giardiasis

[2] Romain Rotival, et al. Determination of quinacrine dihydrochloride dihydrate stability and characterization of its degradants

[3] Aida M Cancel, et al. A one-year neonatal mouse carcinogenesis study of quinacrine dihydrochloride

[4] M J Van Beek, et al. Antimalarials

[5] J Zipper, et al. Quinacrine revised

Related Anti-infection Products

Fomivirsen is a phosphorothioate oligonucleotide derivative that binds to and degrades the mRNA of the CMV immediate-early 2 protein, thereby inhibiting viral proliferation, and can be used in studies related to cytomegalovirus retinitis (CMV).


Bucillamine is an orally active endogenous cysteine derivative of the amino acid that also acts as a sulfhydryl donor with antiangiogenic, antioxidant, and anti-inflammatory activities, and is used in rheumatoid arthritis (RA), cystinuria, and gout studies.

β-Amyrin acetate

β-Amyrin acetate is a triterpenoid natural product that localizes to HMG CoA reductase and inhibits its activity, with potent anti-inflammatory, anti-fungal, anti-diabetic, and anti-hyperlipidemic activities.

Rabbit defensin NP-1

Rabbit defensin NP-1, a defensin isolated from rabbit neutrophils, consists of 33 amino acids rich in arginine and cysteine residues and has antimicrobial activity.

Human β-defensin-3

Human β-defensin-3 is an antimicrobial peptide produced by epithelial cells that reduces inflammatory cytokine responses, as well as inhibits microbial growth, and has immunomodulatory activity with IC90 values ranging from 6-25 μg/ml.

Abmole Inhibitor Catalog

Keywords: Quinacrine dihydrochloride, Mepacrine dihydrochloride; SN-390 supplier, Anti-infection, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.