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QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC50 of 7 nM.
| Molecular Weight | 447.49 |
| Formula | C27H21N5O2 |
| CAS Number | 1469988-75-7 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[4] Hong Wu, et al. ACS Chem Biol. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma
| Related BTK Products |
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BIIB129 is a covalent, selective inhibitor of Bruton's tyrosine kinase (BTK) capable of penetrating the blood-brain barrier. BIIB129 inhibits the activity of BTK by covalently binding to Cys481 in BTK, thereby affecting the function of B cells and myeloid cells. |
| UBX-382
UBX-382 is an orally available proteolysis-targeting chimeras (PROTACs) that target BTK to inactivate B-cell receptor signaling. |
| GDC-0834
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N-piperidine Ibrutinib hydrochloride is a reversible Ibrutinib derivative. |
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