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Pyr6

Cat. No. M8479

All AbMole products are for research use only, cannot be used for human consumption.

Pyr6 Structure
Synonym:

N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide

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Quality Control & Documentation
Biological Activity

Pyr6 is a selective inhibitor of calcium release from the endoplasmic reticulum via STIM1/Orai1 mediated, store operated calcium entry (SOCE). Pyr6 blocks SOCE in thapsigargin treated, calcium depleted BRL-2H3 cells (IC50 = 0.49 μM), but has poor activity against carbachol-induced, TRPC3-mediated calcium entry in TRPC3-transfected HEK293 cells (IC50 = 18.46 μM).

Chemical Information
Molecular Weight 418.27
Formula C17H9F7N4O
CAS Number 245747-08-4
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] caro Arajo de Sousa, et al. Inhibitory effect of Pyr6 (an Orai channel blocker) on agonist-induced contractions in rat uterus

[2] Janyerson Dannys Pereira da Silva, et al. Pharmacological characterization of the calcium influx pathways involved in nitric oxide production by endothelial cells

[3] Hyun Jong Kim, et al. Differential modulation of TWIK-related K + channel (TREK) and TWIK-related acid-sensitive K + channel 2 (TASK2) activity by pyrazole compounds

[4] Juma A M Ali, et al. Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms

[5] Takashi Makiuchi, et al. Evolutionary analysis of synteny and gene fusion for pyrimidine biosynthetic enzymes in Euglenozoa: an extraordinary gap between kinetoplastids and diplonemids

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Keywords: Pyr6, N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide supplier, inhibitors, activators

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