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Pseudolycorine

Cat. No. M29851
Pseudolycorine Structure
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Biological Activity

Pseudolycorine is an Amaryllidaceae alkaloid with anticancer activity.

Chemical Information
Molecular Weight 289.33
Formula C16H19NO4
CAS Number 29429-03-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ngoc-Thao-Hien Le, et al. Molecules. Anti-SARS-CoV-2 Activity and Cytotoxicity of Amaryllidaceae Alkaloids from Hymenocallis littoralis

[2] Gan Zhang, et al. Pharm Biol. Pseudolycorine chloride ameliorates Th17 cell-mediated central nervous system autoimmunity by restraining myeloid-derived suppressor cell expansion

[3] Deepali Katoch, et al. Nat Prod Res. Pseudolycorine N-oxide, a new N-oxide from Narcissus tazetta

[4] Biyang Deng, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Determination of pseudolycorine in the bulb of lycoris radiata by capillary electrophoresis combined with online electrochemiluminescence using ultrasonic-assisted extraction

[5] Gwendoline Van Goietsenoven, et al. J Nat Prod. Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells

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