Protamine sulfate is a positive ionic peptide with anti-heparin activity. Protamine sulfate has strong alkaline groups, which combine with strongly acidic heparin in the body to form a stable compound, making heparin lose its anticoagulant ability.
| Formula | H2O4S |
| CAS Number | 9009-65-8 |
| Solubility (25°C) | Water ≥ 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Vance G Nielsen, et al. Anesth Analg. Protamine sulfate: crouching clot or hidden hemorrhage?
[4] No authors listed. J Am Med Assoc. PROTAMINE sulfate
[5] R Porsche, et al. Heart Lung. Allergy to protamine sulfate
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