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Protamine sulfate

Cat. No. M21584
Protamine sulfate  Structure
Size Price Availability Quantity
200mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Protamine sulfate is a positive ionic peptide with anti-heparin activity. Protamine sulfate has strong alkaline groups, which combine with strongly acidic heparin in the body to form a stable compound, making heparin lose its anticoagulant ability.

Chemical Information
Formula H2O4S
CAS Number 9009-65-8
Solubility (25°C) Water ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jesse M Young, et al. Antimicrob Agents Chemother. Protamine Sulfate Is a Potent Inhibitor of Human Papillomavirus Infection In Vitro and In Vivo

[2] John Phair, et al. Vascular. Protamine sulfate use during tibial bypass does not appear to increase thrombotic events or affect short-term graft patency

[3] Vance G Nielsen, et al. Anesth Analg. Protamine sulfate: crouching clot or hidden hemorrhage?

[4] No authors listed. J Am Med Assoc. PROTAMINE sulfate

[5] R Porsche, et al. Heart Lung. Allergy to protamine sulfate

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