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Pronase E (Activity ≥ 7000 U/g)

Cat. No. M19983
Pronase E (Activity ≥ 7000 U/g) Structure
Synonym:

Pronase (Activity ≥ 7000 U/g)

Size Price Availability Quantity
100mg USD 58  USD58 In stock
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Quality Control & Documentation
Biological Activity

Pronase E (Activity ≥ 7000 U/g) is a proteolytic enzyme mixture obtained from Streptomyces griseus that is able to digest proteins into individual amino acids.

Chemical Information
CAS Number 9036-06-0
Solubility (25°C) DMSO ≥ 40 mg/mL
Water 20 mg/mL
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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