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Promethazine

Cat. No. M20988
Promethazine Structure
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Biological Activity

Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.

Chemical Information
Molecular Weight 284.42
Formula C17H20N2S
CAS Number 60-87-7
Solubility (25°C) DMSO 29 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jenna M Moodley, et al. Nursing. Why remove injectable promethazine from the formulary?

[2] C Cantisani, et al. Biomed Res Int. Topical promethazine side effects: our experience and review of the literature

[3] No authors listed. Prescrire Int. Injectable promethazine: gangrene

[4] T DeGrandi, et al. Pediatr Emerg Care. Promethazine-induced dystonic reaction

[5] G B Hickson, et al. Pediatrics. Should promethazine in liquid form be available without prescription?

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