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Prochloraz

Cat. No. M21632
Prochloraz Structure
Synonym:

BTS 40542

Size Price Availability Quantity
250mg USD 40  USD40 In stock
500mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM.

Chemical Information
Molecular Weight 376.67
Formula C15H16Cl3N3O2
CAS Number 67747-09-5
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xuheng Gao, et al. Pestic Biochem Physiol. Monitoring and characterization of prochloraz resistance in Fusarium fujikuroi in China

[2] Jiajian Huang, et al. Toxics. Dissipation and Distribution of Prochloraz in Bananas and a Risk Assessment of Its Dietary Intake

[3] Beatriz Salesa, et al. Chemosphere. The prochloraz chronic exposure to Daphnia magna derived in biochemical alterations of F0 generation daphnids and malformed F1 progeny

[4] Qin Peng, et al. Plant Dis. Characterization of Prochloraz Resistance in Fusarium fujikuroi from Heilongjiang Province in China

[5] Anne Marie Vinggaard, et al. Int J Androl. Prochloraz: an imidazole fungicide with multiple mechanisms of action

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