Pristinamycin IA (Mikamycin B; Mikamycin IA), a biologically active decapeptide isolated from the skin of the Australian frog Hyla caerulea, is a potent cholecystokinetic agent, and acts as a cholecystokinin receptor agonist. Pristinamycin IA (100 μM, 0-4 h) inhibits the efflux of [3H]vinblastine from Caco-2 cells.
| Molecular Weight | 866.96 |
| Formula | C45H54N8O10 |
| CAS Number | 3131-03-1 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Andrea T Feler, et al. Plasmid. Mobile lincosamide resistance genes in staphylococci
[3] Andrea T Feler, et al. Plasmid. Mobile macrolide resistance genes in staphylococci
[4] Steeve Gigure, et al. Microbiol Spectr. Antimicrobial Resistance in Rhodococcus equi
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