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PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models.
PRGL493 inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 μM. PRGL493 (5 μM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells.
PRGL493 inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.
| Molecular Weight | 451.48 |
| Formula | C25H21N7O2 |
| CAS Number | 2479378-45-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 4 mg/mL Chloroform 1 mg/mL |
| Storage | -20°C, sealed |
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