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PPADS is a non-selective P2X receptor antagonist. PPADS blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS is an inhibitor of the reverse mode of the Na/Ca2+ exchanger in guinea pig airway smooth muscle.
| Molecular Weight | 511.38 |
| Formula | C14H14N3O12PS2 |
| CAS Number | 149017-66-3 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Marie E Gibbs, et al. ATP derived from astrocytes modulates memory in the chick
[4] Brian D Gulbransen, et al. Purinergic neuron-to-glia signaling in the enteric nervous system
| Related P2 Receptor Products |
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| BzATP triethylammonium
BzATP triethylammonium salt acts as a P2X receptor agonist with pEC50s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively. |
| NF449
NF449 is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. |
| NF279
NF279 is a potent selective and reversible P2X1 receptor antagonist, with an IC50 of 19 nM. |
| NF110
NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). |
| PSB-12062
PSB-12062 is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4. |
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