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Poly-D-lysine hydrobromide (30,000-70,000)

Cat. No. M10150
Poly-D-lysine hydrobromide (30,000-70,000) Structure
Synonym:

D-Lysine homopolymer hydrobromide

Size Price Availability Quantity
10mg USD 110  USD110 In stock
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Quality Control & Documentation
  • Purity: mol wt 30,000-70,000
  • COA
  • MSDS
Biological Activity

Poly-D-lysine polymers can be used in preparing surfaces for cell attachment. The D-lysine polymers can also be used with cells that digest poly-L-lysine polymers and cause an excessive uptake of L-lysine.

This product is recommended as a cell culture substratum when using 0.5 - 1.0 mL of a 0.1 mg/mL solution to coat 25 cm2. Lower molecular weight versions of the product are less viscous, but high more molecular weight versions provide more attachment sites per molecule.

Chemical Information
Formula (C6H12N2O2)n.xHBr
CAS Number 27964-99-4
Solubility (25°C) Water
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jingying Gao, et al. Eur J Pharmacol. Inhibition of voltage-gated potassium channels mediates uncarboxylated osteocalcin-regulated insulin secretion in rat pancreatic β cells

[2] Jean-Pierre Karam, et al. J Control Release. Pharmacologically active microcarriers associated with thermosensitive hydrogel as a growth factor releasing biomimetic 3D scaffold for cardiac tissue-engineering

[3] Maya Muramatsu, et al. Am J Physiol Gastrointest Liver Physiol. Activation of the gut calcium-sensing receptor by peptide agonists reduces rapid elevation of plasma glucose in response to oral glucose load in rats

[4] Feng Wang, et al. Sheng Li Xue Bao. [Migratory properties of vascular smooth muscle cells on extracellular matrix: a study on inverted coverslip migration assay]

[5] G R Dubes, et al. Acta Virol. Influence of polypeptide molecular and side chain lengths and of side chain steric location on the kinetics of basic polypeptide-induced sensitization of primate cells to transfection

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Keywords: Poly-D-lysine hydrobromide (30,000-70,000), D-Lysine homopolymer hydrobromide supplier, inhibitors, activators


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