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Poly-D-lysine hydrobromide (70,000-150,000)

Cat. No. M21439
Poly-D-lysine hydrobromide (70,000-150,000) Structure
Synonym:

Poly-D-lysine HBr

Size Price Availability Quantity
10mg USD 125  USD125 In stock
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Quality Control & Documentation
  • Purity: mol wt 70,000-150,000
  • COA
  • MSDS
Biological Activity

Poly-D-lysine hydrobromide (70,000-150,000)

Chemical Information
Formula (C6H12N2O2)n.xHBr
CAS Number 27964-99-4
Solubility (25°C) Water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jingying Gao, et al. Eur J Pharmacol. Inhibition of voltage-gated potassium channels mediates uncarboxylated osteocalcin-regulated insulin secretion in rat pancreatic β cells

[2] Jean-Pierre Karam, et al. J Control Release. Pharmacologically active microcarriers associated with thermosensitive hydrogel as a growth factor releasing biomimetic 3D scaffold for cardiac tissue-engineering

[3] Maya Muramatsu, et al. Am J Physiol Gastrointest Liver Physiol. Activation of the gut calcium-sensing receptor by peptide agonists reduces rapid elevation of plasma glucose in response to oral glucose load in rats

[4] Feng Wang, et al. Sheng Li Xue Bao. [Migratory properties of vascular smooth muscle cells on extracellular matrix: a study on inverted coverslip migration assay]

[5] G R Dubes, et al. Acta Virol. Influence of polypeptide molecular and side chain lengths and of side chain steric location on the kinetics of basic polypeptide-induced sensitization of primate cells to transfection

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