Podophyllotoxin (Podofilox) is a lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.
| Cell Experiment | |
|---|---|
| Cell lines | Human glioma cell lines CL5 |
| Preparation method | After the Etoposide treatment, removing cells from the dish with phosphate-buffered saline (PBS) containing 0.03% trypsin and 0.27 mM ethylenediaminetetraacetic acid (EDTA) and diluting into culture dishes in appropriate numbers to yield between 20 and 200 colonies. 12 days later, fixing cultures with methanol-acetic acid, staining with crystal violet, and scoring for colonies containing more than 50 cells. The standard errors are typically less than 15% of the mean value unless otherwise stated. |
| Concentrations | 80 μg/mL |
| Incubation time | 1 hour |
| Animal Experiment | |
|---|---|
| Animal models | Murine angiosarcoma xenografts ISOS-1 |
| Formulation | Saline |
| Dosages | 10 mg/kg |
| Administration | i.p. every day for 5 days from day 7 |
| Molecular Weight | 414.41 |
| Formula | C22H22O8 |
| CAS Number | 518-28-5 |
| Solubility (25°C) | DMSO 63 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Zinnia Shah, et al. Podophyllotoxin: History, Recent Advances and Future Prospects
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