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PNU 37883 hydrochloride

Cat. No. M7149

All AbMole products are for research use only, cannot be used for human consumption.

PNU 37883 hydrochloride Structure

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Quality Control & Documentation
Biological Activity

PNU 37883 hydrochloride is a novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.

Chemical Information
Molecular Weight 381.98
Formula C21H35N3O.HCl
CAS Number 57568-80-6
Solubility (25°C) DMSO 9.55 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kim, et al. Proc Natl Acad Sci USA. Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors.

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