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Cat. No. M9008
PLX7904 Structure


Size Price Availability Quantity
5mg USD 165  USD165 In stock
10mg USD 300  USD300 In stock
50mg USD 1350  USD1350 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

PLX7904 is a potent and selective BRAF inhibitor, with IC50 of appr 5 nM against BRAFV600E in mutant RAS expressing cells. PLX7904 potently inhibit ERK1/2-driven GAL4-Elk1 reporter activity in PRT cells as well as parental cells. PLX7904 potently inhibits phosphorylation of ERK1/2 in mutant BRAF melanoma cells without eliciting paradoxical activation in wild-type BRAF, mutant NRAS melanoma cells.

In vivo, PLX7904 inhibits the COLO205 xenograft growth in eight mice per group.

Cell Experiment
Cell lines WM793, WM115, WM9, WM278, WM1346, WM1366, WM1361A, Sbcl2, 1205Lu, A375, SK-MEL 24, SKMEL-2, and SK-MEL 207 cells
Preparation method Cells are treated with PLX7904 at different concentrations (0, 0.05, 0.1, 1, 5 μM) for 24 h. Cells are lysed and analyzed by Western blotting with phospho-MEK1/2, total MEK1/2, phospho-ERK1/2 and total ERK1/2 antibodies.
Concentrations 0, 0.05, 0.1, 1, 5 μM
Incubation time 24 h
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 512.53
Formula C24H22F2N6O3S
CAS Number 1393465-84-3
Purity >98%
Solubility DMSO: ≥ 40 mg/mL
Storage at -20°C

[1] Zhang C, et al. Nature. RAF inhibitors that evade paradoxical MAPK pathway activation.

[2] Basile KJ, et al. Pigment Cell Melanoma Res. Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors.

[3] Le K, et al. Pigment Cell Melanoma Res. Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells.

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Abmole Inhibitor Catalog

Keywords: PLX7904, PB04 supplier, Raf, inhibitors

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