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PLX 647 dihydrochloride is a potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.
| Molecular Weight | 455.3 |
| Formula | C21H17F3N4.2HCl |
| CAS Number | 1779796-38-1 |
| Solubility (25°C) | DMSO 45.53 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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