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(+)-Kavain

Cat. No. M19452
(+)-Kavain Structure
Synonym:

(R)-(+)-Kavain

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Biological Activity

(+)-Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels.

Chemical Information
Molecular Weight 230.26
Formula C14H14O3
CAS Number 500-64-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Thas Teixeira da Silva, et al. J Toxicol Environ Health A. Modulating effect of DL-kavain on the mutagenicity and carcinogenicity induced by doxorubicin in Drosophila melanogaster

[2] H Madhavaram, et al. J Anal Toxicol. Kavain Interference with Amphetamine Immunoassay

[3] Manish Chamoli, et al. MicroPubl Biol. Kavain suppresses human Aβ-induced paralysis in C. elegans

[4] Pengcheng Wang, et al. Chem Res Toxicol. Enzymes and Pathways of Kavain Bioactivation and Biotransformation

[5] Shailendra P Singh, et al. J Immunol. Kavain Reduces Porphyromonas gingivalis- Induced Adipocyte Inflammation: Role of PGC-1α Signaling

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