Poly(D,L-lactide-co-glycolide) is a synthetic amino acid that has been used to deliver macromolecular therapeutics. The transition temperature (Tg) is 45 ~ 55℃ when the molecular weight is above 30,000. When the molecular weight is below 30,000, the transition temperature (Tg) decreases gradually. It is soluble in most organic solvents such as methylene chloride, tetrahydrofuran, ethyl acetate, acetone, chloroform, and hexafluoroispropanol.
| Formula | (C3H4O2)x(C2H2O2)y |
| CAS Number | 26780-50-7 |
| Solubility (25°C) | Soluble in methylene chloride tetrahydrofuran ethyl acetate acetone chloroform |
| Storage | -20°C, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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