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Plazomicin Sulfate

Cat. No. M40756
Plazomicin Sulfate Structure
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Biological Activity

Plazomicin Sulfate is a derivative of Sisomicin and a novel aminoglycoside antibiotic that binds to the bacterial 30S ribosomal subunit, thereby inhibiting protein synthesis in a concentration-dependent manner, with broad-spectrum antimicrobial activity against aerobic Gram-negative bacteria, and can be used in studies related to pyelonephritis.

Chemical Information
Molecular Weight 690.76
Formula C25H50N6O14S
CAS Number 1380078-95-4
Form Solid
Storage -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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