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Piscidic acid

Cat. No. M18976
Piscidic acid Structure
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10mg USD 1500  USD1500 In stock
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Biological Activity

Piscidic acid

Chemical Information
CAS Number 469-65-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Meriam Missaoui, et al. Molecules. Characterization of Micronutrients, Bioaccessibility and Antioxidant Activity of Prickly Pear Cladodes as Functional Ingredient

[2] Victoria Werner, et al. Planta. A BAHD hydroxycinnamoyltransferase from Actaea racemosa catalyses the formation of fukinolic and cimicifugic acids

[3] Asma Ressaissi, et al. Arch Pharm Res. Isorhamnetin derivatives and piscidic acid for hypercholesterolemia: cholesterol permeability, HMG-CoA reductase inhibition, and docking studies

[4] S O Kruse, et al. Planta Med. Fukiic and piscidic acid esters from the rhizome of Cimicifuga racemosa and the in vitro estrogenic activity of fukinolic acid

[5] B J He, et al. Yao Xue Xue Bao. [Studies on an aqueous soluble active constituent of Chuan-Shan-Long (Dioscorea nipponica Makino). I. Isolation and identification of p-hydroxy benzyl tartaric acid (piscidic acid) (author's transl)]

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