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Pirodavir

Cat. No. M3711

All AbMole products are for research use only, cannot be used for human consumption.

Pirodavir Structure
Synonym:

R77975

Size Price Availability Quantity
1mg USD 57 In stock
5mg USD 150 In stock
10mg USD 206 In stock
25mg USD 375 In stock
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Quality Control & Documentation
Biological Activity

Pirodavir (R77975) is a capsid - bound anti-picornavirus compound that is active in vitro against most rhinovirus (RV) serotypes. Pirodavir is a potent, broad-spectrum picornavirus inhibitor. Pirodavir inhibits 80 of the 100 human rhinovirus (HRV) strains tested at a concentration of 64 ng/mL. In that same study, Pirodavir is also effective in inhibiting 16 enteroviruses, with a mean 80% inhibitory concentration (IC80) of 1,300 ng/mL. Pirodavir inhibits enterovirus 71 replication with an IC50 of 5,420 nM and an IC90 of >13,350 nM. Pirodavir inhibits 56 rhinovirus laboratory strains and three of the clinical isolates tested. Pirodavir inhibits 59% of the serotypes and isolates with IC50s of <100 nM.

Product Citations
Chemical Information
Molecular Weight 369.46
Formula C21H27N3O3
CAS Number 124436-59-5
Solubility (25°C) DMSO 10 mg/mL
Ethanol 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hayden FG, et al. Antimicrob Agents Chemother. Intranasal pirodavir (R77,975) treatment of rhinovirus colds.

[2] Hayden FG, et al. Antimicrob Agents Chemother. Safety and efficacy of intranasal pirodavir (R77975) in experimental rhinovirus infection.

[3] Andries K, et al. Antimicrob Agents Chemother. In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity.

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Keywords: Pirodavir, R77975 supplier, Anti-infection, inhibitors, activators

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