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Pilloin

Cat. No. M40126
Pilloin Structure
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Biological Activity

Pilloin, a flavonoid isolated from Marrubium cylleneum, exerts a cytotoxic action targeted at the transformed lymphoblasts. Pilloin also possesses anti-inflammatory activity.

Chemical Information
Molecular Weight 314.29
Formula C17H14O6
CAS Number 32174-62-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Min-Ji Keem et al. Nutrients. A High-Performance Liquid Chromatography with Photodiode Array Detection Method for Simultaneous Determination of Three Compounds Isolated from Wikstroemia ganpi: Assessment of the Effects on Cytochrome P450-Mediated Metabolism In Vitro and In Vivo

[2] Claudio Frezza et al. Biomolecules. Phytochemical Analysis and Biological Activities of the Ethanolic Extract of Daphne sericea Vahl Flowering Aerial Parts Collected in Central Italy

[3] Josiane A Monteiro de Oliveira et al. Nat Prod Res. New cadinene-sesquiterpene from Chromolaena laevigata (lam.) R. M. King & H. Rob (Asteraceae) aerial parts and biological activities

[4] Yun-Chen Tsai et al. Molecules. Pilloin, A Flavonoid Isolated from Aquilaria sinensis, Exhibits Anti-Inflammatory Activity In Vitro and In Vivo

[5] Hari Prasad Devkota et al. Biosci Biotechnol Biochem. Pilloin 5-O-β-D-glucopyranoside from the stems of Diplomorpha ganpi

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