All AbMole products are for research use only, cannot be used for human consumption.
PIK-90 is a novel and potent PI3K inhibitor with IC50 values of 11 nM, 350 nM, 18 nM and 58 nM for p110α, p110β, p110γ and p110δ respectively. Phosphoinositide 3-kinases (PI3Ks) are among the most frequently activated signaling pathways in cancer. Inhibition with p110alpha inhibitor PIK-90 resulted in a significant reduction of chemotaxis and actin polymerization to CXCL12 and reduced migration beneath MSC (pseudoemperipolesis). In suspension and MSC cocultures, PIK-90 was potent inducers of CLL cell apoptosis.
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Source | Proc Natl Acad Sci U S A (2012). Figure 1.PIK-90 |
| Method | apoptosis assay | |
| Cell Lines | PTENWT and PTENMT glioma cell lines | |
| Concentrations | 0.5 μM | |
| Incubation Time | 24 h | |
| Results | Like PIK-90, PI-103, and LY294002, PIK-75 could block phosphorylation of Akt |
| Cell Experiment | |
|---|---|
| Cell lines | LN229:EGFR (PTENwt) and U87:EGFR (PTENmt) cells |
| Preparation method | Cell proliferation assay and flow cytometry. For viability, 10^5 cells were seeded in 12-well plates in the presence of erlotinib, PI-103, PIK-90, rapamycin, erlotinib plus PIK-90, erlotinib plus rapamycin, erlotinib plus PIK-90, and rapamycin or erlotinib plus PI-103 for 72 h. Cell viability was determined using a WST-1 assay (AbMole). |
| Concentrations | 0, 0.1, 0.5, 1µM |
| Incubation time | 72h |
| Animal Experiment | |
|---|---|
| Animal models | Human primary GBM43 cells female BALB/c nu/nu mice bearing xenografts model |
| Formulation | DMSO:H20 |
| Dosages | 40 mg/kg |
| Administration | daily i.p. |
| Molecular Weight | 351.36 |
| Formula | C18H17N5O3 |
| CAS Number | 677338-12-4 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PI3K Products |
|---|
| PI3Kγ inhibitor AZ2
PI3Kγ inhibitor AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). |
| NIBR-17
NIBR-17 is a pan-class I PI3K inhibitor with suitable pharmacokinetic properties and inhibits tumor growth. |
| RV-1729
RV-1729 is an inhibitor of the phosphatidylinositol 3-kinase-δ (PI3Kδ). |
| Vulolisib
Vulolisib is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC50 values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. |
| Vps34-IN-4
Vps34-IN-4 is a potent, selective, and orally active inhibitor of VPS34. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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