Free shipping on all orders over $ 500

Physalin C

Cat. No. M39129
Physalin C Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells.

Chemical Information
Molecular Weight 510.53
Formula C28H30O9
CAS Number 27503-33-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yang Li et al. Molecules. A Rapid and Sensitive LC-MS/MS Method for the Quantitation of Physalin A with Special Consideration to Chemical Stability in Rat Plasma: Application to a Pharmacokinetic Study

[2] Renxing Zhong et al. J Ethnopharmacol. Physalin B ameliorates inflammatory responses in lipopolysaccharide-induced acute lung injury mice by inhibiting NF-κB and NLRP3 via the activation of the PI3K/Akt pathway

[3] Liying Wang et al. J Ethnopharmacol. Anti-inflammatory action of physalin A by blocking the activation of NF-κB signaling pathway

[4] Yu-Hsien Lin et al. Toxicol Appl Pharmacol. Physalin A attenuates inflammation through down-regulating c-Jun NH2 kinase phosphorylation/Activator Protein 1 activation and up-regulating the antioxidant activity

[5] Qiao Zhang et al. J Ethnopharmacol. Anti-colitic effects of Physalin B on dextran sodium sulfate-induced BALB/c mice by suppressing multiple inflammatory signaling pathways

Related Metabolite/Endogenous Metabolite Products
Isocitric acid trisodium salt

Isocitric acid trisodium salt is an endogenous metabolite. Isocitric acid trisodium salt is a substrate in the citric acid cycle. Isocitric acid trisodium salt can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia.
Phytanic acid

Phytanic acid is an endogenous metabolite present in blood.

2,3-Dihydroxyisovaleric acid

2,3-Dihydroxyisovaleric acid is a natural metabolite of the branched-chain amino acid leucine. It acts by activating the mTOR signaling pathway to promote the synthesis of new muscle proteins and reduce the breakdown of existing proteins.
Ursocholic acid

Ursocholic acid is a bile acid found predominantly in bile of mammals, which can be transformed into deoxycholic acid by the intestinal microflora in mice.

5β-Cholanic acid

5β-Cholanic acid can be used for 5β-Cholanic acid derivatives synthesis.
  Catalog
Abmole Inhibitor Catalog




Keywords: Physalin C supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.