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Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required for the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 499.98 |
| Formula | C5H14NaO14P3 |
| CAS Number | 108321-05-7 |
| Purity | >80% |
| Solubility | Water ≥ 40 mg/mL |
| Storage | -20°C , dry , sealed |
| Related Endogenous Metabolite Products |
|---|
| Hexadecanedioic acid
Hexadecanedioic acid is a common saturated fatty acid. Hexadecanedioic acid and Sepharose 4B are bound by covalent bond, which is more specific than dye resin and can be used to remove serum albumin (SA) from plasma. |
| Cinnamoylglycine
Cinnamoylglycine is a human urine metabolite, a glycine conjugate of cinnamic acid and. Cinnamoylglycine is used as a urine marker, which can be used as a marker for colonization of drug resistance after the antibiotic study period. |
| Ompenaclid
Ompenaclid (RGX-202) is an orally active inhibitor of SLC6A8 transport protein. RGX-202 strongly inhibits creatine import in vitro and in vivo, decreases intracellular phosphocreatine and ATP levels, and induces apoptosis. RGX-202 has been used in oncology and Duchenne muscular dystrophy studies. |
| α-Muricholic acid
Alpha-Muricholic acid is one of the most abundant bile acids in rodents. |
| L-Dihydroorotic acid
L-dihydroorotic acid (L-dihydroorotate) is an intermediate product of pyrimidine metabolism that can be reversibly hydrolyzed by dihydroorotase to yield acyclic L-ureidosuccinic acid. |
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