Phosphatidylcholines, soya is a kind of extracted from soybean phosphatidyl choline, can be used for the preparation of liposomes. Has been shown to play important roles in many important areas, including maintenance of cellular structure, fat metabolism, memory, nerve signaling, acting as a precursor of important neurotransmitters, and liver health. Phosphatidylcholines, soya can be used as animal drug delivery carrier.
Molecular Weight | 758.060261 |
Formula | C42H80NO8P |
CAS Number | 97281-47-5 |
Solubility (25°C) | Ethanol ≥ 40 mg/mL |
Storage | −20°C |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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