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Phentolamine mesylate is safe and effective in the long-term treatment of men with mild to moderate ED. Phentolamine increased catecholamine release by presynaptic alpha 2-blockade, thereby suppressing the autoinhibition of transmitter release. Phentolamine leads to an increase in FBM by preferentially antagonizing presynaptic alpha 2-adrenoreceptors over postsynaptic alpha 1-adrenoreceptors. This influence of phentolamine on FBM may be secondary to its effect on ECoG. Promotion of LV-ECoG by catecholamines is mediated via an alpha 1-independent mechanism.
PLoS Comput Biol. 2024 Apr 5;20(4):e1011945.
A probabilistic knowledge graph for target identification
Phentolamine Mesylate purchased from AbMole
PLoS Comput Biol. 2024 Apr 05;20(4):e1011945.
A probabilistic knowledge graph for target identification
Phentolamine Mesylate purchased from AbMole
| Molecular Weight | 377.46 |
| Formula | C18H23N3O4S |
| CAS Number | 65-28-1 |
| Solubility (25°C) | DMSO 75 mg/mL Water 75 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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