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Phenoxybenzamine hydrochloride is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM. It is used as an anti-hypertensive due to its efficacy in reducing the vasoconstriction caused by adrenaline and noradrenaline. Phenoxybenzamine forms a permanent covalent bond with adrenergic receptors. It remains permanently bound to the receptor, preventing adrenaline and noradrenaline from binding. This causes vasodilatation in blood vessels, due to its antagonistic effect at the alpha-1 adrenoceptor found in the walls of blood vessels, resulting in a drop in blood pressure.?
| Molecular Weight | 340.3 |
| Formula | C18H22ClNO.HCl |
| CAS Number | 63-92-3 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] National Toxicology Program. Phenoxybenzamine hydrochloride
[3] National Toxicology Program. Phenoxybenzamine hydrochloride
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